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No drugs specifically target dengue virus.
Development of an active surveillance system incorporating geographic information systems would enable health authorities to better monitor distribution and intensity of acute infections, identify high-risk areas, and target dengue control activities (7 ).
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As shown in Table 1, among the 15 top ranked probes, eight targeted dengue virus specifically, while a further four probes targeted related flavivirueses such as Phnom Penh bat virus, Tembusu virus, and deer tick virus.
Together, these new findings highlight NS1 as an instigator of dengue-associated vascular leak and thus pinpoint a potential target for dengue drugs and component for dengue vaccines.
The loops at the top contain the critical neutralizing epitopes, and thus, this protein is important for the development of vaccines and therapeutics targeting the dengue virus.
Myeloid cells are major targets of dengue infection in humans.
Mononuclear phagocytes are considered to be main targets for Dengue Virus (DENV) replication.
Open access tools are especially important in resource-limited settings, and analysis packages targeted to dengue are becoming available [ 76].
However, these procedures might help to target some symptomatic dengue importations for an immediate self-quarantine that might mitigate some local dengue transmissions.
Since the principal dengue target cells are monocytic cells including monocyte, macrophage and dendritic cells [36] [38] and HIV infects macrophage and CD4+ T cells, it may be expected that dengue and HIV infections directly stimulate relevant human cells to make IFNα, but not IFNβ.
We previously used a rudimentary version of the block conservation analysis for vaccine target discovery in dengue virus (DENV) [ 30] and reported a 10-fold larger number of potential CD8+ vaccine target candidates as compared to an earlier benchmark study of DENV vaccine target candidates [ 31].
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