Sentence examples for target checkpoint from inspiring English sources

Efforts have been taken to target checkpoint kinase 1 (chk1; approved gene symbol CHEK1), a crucial checkpoint modulator, for therapeutic intervention.

Although treatment options for NSCLC are limited, a better understanding of the immune profile of this disease has facilitated the development of immunotherapeutics that target checkpoint blockade molecules, and clinical evaluation to date supports combining checkpoint blockade with chemotherapy for squamous NSCLC.

Currently, the most advanced available therapeutics developed for lung cancer are monoclonal antibodies that target checkpoints of the immune regulation cascade.

Among them combinations of vaccines with cytokines, inhibitors of metabolic pathways, modulators of baseline inflammation levels, monoclonal antibodies targeting checkpoint inhibitors and compounds depleting of regulatory cells.

There have been more than 12 car bombs in the local area, most targeting checkpoints run by the Islamic Front, a coalition of Islamist-minded groups.

"The attacks targeted checkpoints run by Kurdish fighters on the western entrance of the city.

Some reports suggest that the ATM and ATR kinases target specific checkpoint components depending on the genomic lesion identified, while others suggest that it is not in fact lesion recognition, but the processing of diverse lesions by distinct DNA repair factors which ultimately recruits and activates particular checkpoint components [43], [44].

One such target is checkpoint kinase-1 (Chk1).

Several oncogenic viruses encode proteins that precisely target this checkpoint with potentially catastrophic consequences on the karyotype of surviving cells.

Furthermore, it is also important to analyze other properties, such as half‐life of administered antibody and sustained binding to target immune checkpoint molecules (pharmacodynamics).

12, 16, 17 Recent advances in the development of inhibitory agents, which target key checkpoint molecules within metabolic pathways of melanoma cells, have led to a range of new experimental therapies.