Sentence examples for target can be regulated from inspiring English sources

We noted that in the forward predictions, a target can be regulated by quite a lot of regulation factors: for instance, PLEC1, DMD, and BDNF were associated with more than 50 TFs, inconsistent with the observation that a gene is rarely regulated by more than 20 regulators [ 7].

Therefore, a specific miRNA may simultaneously regulate multiple targets, while a single target can be regulated by multiple miRNAs [ 3].

Remarkably, each miRNA can regulate the expression of numerous target genes and also the same target gene can be regulated by several types of miRNAs which create a complex network of interactions [ 35– 35].

Implications and future directions These findings identify a commonality in four different mouse models of MS. In all four models, protein hypercitrullination resulted from upregulation of PADs, and these enzymes seem to be a therapeutic target that can be regulated by the small-molecule inhibitor 2CA.

Cargo ubiquitylation favors their lysosomal targeting and can be regulated by external signals, but the mechanism is ill-defined.

Thus, a many-to-many relationship structure can be established in miRNAs and their target mRNAs, that is: a miRNA can regulate more than one target mRNA and each target mRNA also can be regulated by more than one miRNA[ 15].

Moreover, the smRNA-target interactions are complex, as one smRNA may regulate the expression of more than one target and one mRNA can be regulated by many smRNAs [ 14, 19– 219.

Furthermore, as shown in Figure 4D and 4E, taking use of mir-shRNA duplex or fourplex also provides a potential means to maximally knockdown the target genes whose dosage can be regulated in a controllable fashion.

Individual miRNAs can modulate multiple mRNA targets, and individual mRNAs can be regulated by multiple, distinct miRNAs [ 20].

The majority of the rtTA models, including those expressing transgenes for K-Ras, EGFR, and FGF7, are valuable models in that a small number of cells can be targeted and transgene expression can be regulated both temporally and spatially.

Each miRNA can influence the expression of multiple target mRNAs and each mRNA can be regulated by several miRNAs [ 21].