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However, in the presence of a target DNA, the hybridization between the loop moiety and the target broke the stem duplex.
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When Bolland took over from Sir Stuart Rose in 2010 he set out an ambitious plan to add more than £2.5bn of new sales with the target broken down across the UK, overseas and online.
After hybridization, the loop sequence (16 bases) formed a rigid duplex with the target, breaking the relatively shorter stem duplex (6 bases).
But all previous simple rules, from the gold standard to rigid money-supply targets, broke down.
As a result UK and US special operations' co-operation against al-Qaeda targets broke down for nine months.
The target area broke, chips of green-painted wood dispersed in all directions.
MG Rover fails to hit management's target of breaking even, suffering a £95m loss.
Business owners should know their monthly margin target to break even".
In the end, the Nikkei missed that target, not breaking 13,000 till a week into April.
With 12 games to go in the regular season Wright-Phillips is on target to break Juan Pablo Angel's club record of 19.
Fiat stock and bond prices fell Tuesday after La Repubblica published a report that the company would not reach a target of breaking even this year.
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CEO of Professional Science Editing for Scientists @ prosciediting.com