"target attainment" is correct and usable in written English.
Generally, the phrase is used to refer to the achievement of a goal or objective that was previously set. For example, "The company exceeded its target attainment for the quarter, reaching 20% above their projections."
In silico models suggest that exposures produced by infusions of β-lactam antibiotics generate a greater probability of target attainment than those attained with bolus dosing (13).
Probability of target attainment efficacy/toxicity.
The PK PD breakpoint was defined as the MIC at which the calculated target attainment was ≥95%.
Thus, in combination, the two important factors may reduce PK/PD target attainment in severely ill patients.
Unlike with intermittent administration, continuous infusion provided a probability of target attainment of 100%, regardless of age and weight.
Our study aimed to assess whether ARC impacts negatively on cefazolin pharmacokinetic pharmacodynamics (PK/PD) target attainment and clinical outcome in critically ill patients.
To our knowledge, this is the first study comparing the 24-hour target attainment between CI versus II utilizing the same CVVH system.
The aim of this study was to compare the probability of target attainment (PTA) and the cumulative fraction of response (CFR) for meropenem between administration by bolus injection and a 3-h infusion.
Post-approval, global in vitro surveillance data produced by reference quality antibacterial susceptibility tests together with PK-PD target attainment analyses provide the opportunity to evaluate approved and clinically used antibacterial dosing regimens.
In this analysis, a 5000-patient Monte Carlo simulation was used to determine PD breakpoints, the highest 2-fold MIC in which the probability of bactericidal target attainment (PTA) remained ≥90%.
Indeed, for an intermittent bolus administration, a 4gx4 dose is associated with a very low probability of target attainment, even for the lowest PK/PD target of T > MIC = 50%[32]].
