Importantly, our results also provide new evidence that each additional target attained results in incremental improvement in these outcomes, regardless of which targets are attained, and provide a comprehensive examination of a variety of performance measures and outcomes.
When all five targets were examined, a significant trend of decreased incidence of hospitalization with each additional target attained was seen (Table 3).
The same statistically significant trend of decreased hospital days with each additional target attained was seen when all five targets were examined (Table 3).
In subpopulation analyses of those attaining 0 or 1 targets at baseline, hospital admissions decreased even more strikingly with each additional 6-month target attained [IRR = 2 targets, 0.70 (0.55–0.89); 3 targets, 0.51 (0.40–0.65); 4 or 5 targets, 0.28 (0.16–0.50); P for trend<0.001].
When all five targets were examined, only the attainment of three or more targets was associated with decreased risk mortality, but there was again a strong statistically significant trend of decreased risk with each additional target attained (Table 2).
The trend of decreased payments with each additional target attained was also seen when all five targets were examined (Table 4), but statistical significance was borderline in the adjusted model.
Subpopulation analyses of those attaining 0 or 1 targets at baseline showed that hospital payments decreased with each additional 6-month target attained ($15,835, $12,708, $11,499, and $10,938 for 0 or 1, 2, 3, and 4 or 5 targets, respectively), but the trend was not significant (P = 0.470).
Identifying new drug targets, attaining regulatory approval from government agencies, and refining techniques in drug discovery and development are among the challenges that face the pharmaceutical industry today.
For total number of targets attained, data were collapsed into four categories (zero or one target, two targets, three targets, and four or five targets attained).
There was also a highly significant trend toward decreased incidence with more targets attained.
Also, there was a trend toward decreased payments with more targets attained.
