Surface glycoproteins direct cellular targeting, attachment, and membrane fusion of arenaviruses and are the primary target for neutralizing antibodies.
The aims of this study were to determine whether Epo bioactivity can be preserved by targeting attachment of maleimide-PEGs to engineered cysteine analogs of Epo, and to determine whether the pegylated Epo cysteine analogs have improved pharmacokinetic properties in vivo.
Nanocomposite thin films containing finely dispersed, crystalline In2O3 nanoparticles embedded in SiO2 matrix were fabricated by target-attachment sputtering method.
The person to whom an infant becomes emotionally attached is termed the target of attachment.
GPI-T identifies its protein substrates via a C-terminal signal sequence; features of this sequence target anchor attachment to an internal amide bond (near the C-terminus) at a position that has been termed the ω-site.
The rationale is that GRT more than 180° has a high risk of recurrence and it is essential to target successful attachment in the primary surgery as reoperation is rather complex in these cases and the outcome is often poor.
5 One important feature of most small GTPases are lipid modifications that are posttranslationally attached and facilitate the specific targeting and attachment of the GTPase to intracellular membranes.
At about six months of age infants begin to respond socially to particular people who become the targets of attachment.
During the first two years of life, the presence of targets of attachment tends to mute infants' feelings of fear in unfamiliar situations.
Targets of attachment are usually those persons who respond most consistently, predictably, and appropriately to the baby's signals, primarily the mother but also the father and eventually others.
Infants depend on their targets of attachment not only for food, water, warmth, and relief from pain or discomfort but also for such emotional qualities as soothing and placating, play, consolation, and information about the world around them.
