The target populations and rationale for these populations are outlined in Tables 1, 2, 3, 4, 5, 6 and the Additional files 3, 4, 5, 6, 7. Key References Janssen, I. & LeBlanc, A. G. (2010).
The monitoring of the drug behavior and distribution in biological system can provide information whether drug reaches its desired target, and a biological rationale for the design of new therapeutics.
Describing the European-level policy system through its statement of added value and rationale, target of intervention, and science support organizations, we argue that it is transitioning from a period we term "science in Europe," to a period we refer to as "European science".
The aim of these meetings was to introduce the research objectives, target population, rationale and history of the questionnaire, give detailed discussions of each item in the questionnaire, and plan for instrument translation, adaptation, pre-testing and data collection within the allocated timeframe, which was scheduled to start in March of that year.
Here, we discuss the background and rationale for targeting PERK as a viable therapeutic approach as well as implications of these findings for other neurodegenerative diseases.
In summary downregulation of these pro-metastatic genes by β-catenin knockdown provides further support for the ability of Wnt/β-catenin signaling to regulate the multistep process of tumor progression and rationale for targeting this pathway in malignancy.
Inferior overall survival for the high BMI‐1 expression group provides an additional prognostic definition and rationale for therapeutically targeting BMI‐1.
Our finding also supports the potential and rationale for PI3K targeting strategy in the treatment of malignant glioma having PTEN loss.
Numbering and names of current QIs and their year of introduction, rationale, quality target and DKG/DGS requirements for years 1 and 3 of DKG/DGS certification.
Correlating molecular changes with tumourigenesis has provided one route to the identification of potential drug targets and provides the rationale behind efforts to characterise genetic variation and gene expression in tumours.
