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There is some, albeit limited, evidence that the ubiquitin ligase activities of XIAP and cIAP1 may target active caspase-3 for proteasomal degradation.
More precisely, they seem to target active caspase-9 or -3 and block its activity (Verhagen et al, 2001).
The Tanimoto similarity and overlap between query scaffold and target active dataset were used as a means to rank matches.
As this dataset contains many inactive users (i.e., users that issued too few queries), we first filtered the whole dataset to target active users.
These compounds serve as a starting point for the design of probes that can be used to target active proteases for imaging applications.
We show that given biochemical functions can be entirely suppressed in vivo with camel antibodies (VHHs, nanobodies) that target active sites of cognate enzymes expressed in the cytoplasm.
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Individually randomized controlled trial nested within the targeted case finding arm comparing two alternative types of targeting: Active (A) versus Opportunistic (O).
Another campaign targeted active users and reached 100percentt ROAS within a single day.
Moreover, lactoferrin is an efficient molecule that can be used for targeting active agents directly to the lung.
This chapter discusses prodrugs of poorly soluble compounds, polar compounds, prodrugs targeting active transporters, and prodrugs for targeted tissue delivery.
Anti-cytokine vaccination is an innovative strategy of targeted, active immunotherapy with potential application in autoimmune diseases.
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