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The proposed education fund echoes the type of public health initiatives which systematically target a disease or a health problem with a clearly-defined outcome.
A very crucial requirement for application of an agent for delivery of both drugs and imaging probes to target a disease marker is the capability of the agent to cross the endothelial barrier and to allow for proper tissue penetration and distribution.
The treatment may target a disease, a symptom or a risk factor.
High temperature treatment (37 °C) specifically induced expression of novel476 and novel482 miRNAs that target a disease resistance RPP13-like protein and disease resistance protein RGA2-like, respectively.
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Further studies are needed to examine if this two-hit approach will be useful in constructing therapeutic vectors that target a disease-related gene promoter.
So far, no PSP has targeted a disease with peak prevalence during adolescence in mainly healthy subjects.
In fact, four of the vaccines used in the EPI target a single disease (BCG, AAV, MV, OPV-Oral Polio Vaccine); only one vaccine targets three diseases (DTP).
AD remains difficult to diagnose with the degree of specificity needed for testing therapeutics that target a single disease mechanism.
While the 3P Project is targeting TB – a disease for which MSF treats nearly 40,000 people a year – the principles of alternative funding can be applied to other diseases which suffer from habitual industry neglect.
One of the greatest advantages of this approach is that it enables the discovery of novel therapeutic targets for a disease.
Together, these observations suggest that aggregated tau is not merely a neuropathological marker; tau aggregation rather represents a main target of a disease-modifying therapy for tauopathies.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com