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Theoretically, the shear strength,, of the squeezed bone chip at the thread surroundings is closely related to the tapping function of cutting flute.
We have shown that STN DBS at a variety of low frequencies can slow distal upper limb movements in PD patients with relatively preserved baseline tapping function at the time of study.
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The magnetic stylus is a nice touch, too, as it performs more than just tapping functions.
TAP function is dependent on ATP in order to complete a cycle of peptide translocation.
These results suggest that tap function, although dispensable for fertility in Drosophila, is required for transposon repression in germline cells.
We examined whether tap function is also required for localizing other nuage components to the nuage and vice versa.
Importantly, Qdm processing strictly depends on TAP function, which transports the proteasome-trimmed leader peptides into the ER [ 36].
To analyze tap function, we generated a deletion mutant through imprecise excision of a P-element, EY02725, inserted within an intron of the tap gene.
These results also indicate that Tej and Tap function together for the piRNA pathway, and explain the higher derepression of TEs in double mutants than in tej mutants.
We also showed that tej and tap function in a synergistic manner in a complex for piRNA production to safeguard the germline genome from transposons.
Consistently, the loss of both tej and tap function resulted in mis-localization of Piwi in germline cells, whereas Piwi remained localized to the nucleus in somatic cells.
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