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Exact(29)
They propose that the increase of mitosis outside the ventricular zone underlies the tangential expansion of the gyrencephalic cerebral cortex.
Proliferation of intermediate progenitor cells in ferrets occurs for an extended period compared to rats and may underlie the tangential expansion of the gyrencephalic cerebral cortex in carnivores and primates [17], [18].
In short, multiple factors may mediate tangential expansion and contribute to the pattern specificity of folds.
In the first instance, gyrification is primarily driven by the tangential expansion of the developing cortex.
These variations may contribute to region-specific tangential expansion, resulting in predictable patterns of tangential forces and hence folding.
The third rule is the tangential expansion of the NR during the late phases of eye-cup morphogenesis.
Similar(31)
The second important point is that a number of factors contribute to tangential cortical expansion.
An important implication of this model is that gyrencephaly is a generalized mechanical product of differential tangential surface expansion and is not reducible to a single evolutionary adaptation.
A subsequent modified version of this idea (Toro and Burnod 2005; Xu et al. 2010) suggests that cortical folding arises more simply from tangential surface expansion.
For example, FGF2, the manipulation of which can be used to induce folding, promotes RG self-renewal leading to an increase in tangential cortical expansion (Rash et al. 2013).
Alternatively, it has been proposed that it is the tangential surface expansion that gives rise to in-plane pressure which is dissipated by out-of-plane folding (Le Gros Clark 1945; Ronan et al. 2013) (see Fig. 1).
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