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The TAnDEM study was the first phase III RCT combining a hormonal agent and trastuzumab without chemotherapy as treatment for HER2/hormone receptor copositive metastatic BC Kaufmann et al. [ 18]).
49, 50 In the TAnDEM study, the incidence of grade 3 and 4 AEs was 23% and 5%, respectively, in the trastuzumab plus anastrozole arm, and 15% and 1%, respectively, in the anastrozole alone arm.
Our data are slightly more robust than those of the Phase III SHARP (Sorafenib in Advanced Hepatocellular Carcinoma Assessment Randomized Protocol) trial (10.7 months) 20 and the tandem study in the Asia-Pacific region (6.5 months), probably because our study included a higher number of BCLC stage B patients than were included in the registration trials.
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To confirm the autologous origin, a Short Tandem Report study was performed between MO-LAS and frozen normal skin tissue from the patient.
This fits in well with other tandem studies that have shown PrP is difficult to remove [1], [16], [25], [27] or even impossible [15].
Until recently, muscle and brain ageing had rarely been studied in tandem; however, studies demonstrating improved cognition in later life with increased physical activity have highlighted this important area of research.
Looking at the beliefs in tandem, the study found that greater divine forgiveness diminished the negative association of belief in human sinfulness in seven of the eight mental health outcomes studied.
While in the final system both phases should work in tandem, we studied (optimized, evaluated, etc).
Using this comparative approach, different levels of variation among duplicates were identified among the 47 tandem arrays studied, reflecting various evolutionary dynamics.
Despite the excellent sensitivity and specificity of colonoscopy, miss rates of 2.1% for large adenomas (≥ 10 mm) are reported in tandem colonoscopy studies[ 22].
Furthermore, in the current study, tandem MS (MS/MS) approach was used to distinguish between QA and IA derivatives.
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