Sentence examples for tam effect from inspiring English sources

An overview of Fulv and Tam effect is observed in Figure 9.

The combination regimen succeeded to lower the TAM effect on the secreted MMP 2 and 9 (Fig.  8a, b); the same pattern was observed by the q-PCR technique (Fig.  8c, d) and the Western blot assay (Fig.  9a-d) with antagonistic interaction.

To dissect out that portion of the Tam effect associated with the 'AEBS pathway', we compare here the effects of combining R115,777 with a selective AEBS ligand (N-pyrrolidine -phenylmethyl-phenoxy -ethanamine-HCl (PBPE)) [ 10] or with a selective estrogeN-pyrrolidine -phenylmethyl-phenoxy -ethanamine-HCleratioN-pyrrolidine -phenylmethyl-phenoxy -ethanamine-HCl

However, we believe that the TAM effect was highly important for two reasons: (1) we clearly show that the TAM phenotype was changed during therapy and (2) our macrophage depletion studies (using Clodronate liposomes) showed that loss of TAM significantly reduced the efficacy of combination therapy.

The target genes were picked out through cDNA microarray analysis (unpublished data) according to the rigorous screening criteria: at least two-fold increase in MCF-7R cells compared with MCF-7 cells, at least 1.25-fold induction by TAM, at least 1.5-fold induction by G1, and at least 50% suppression of TAM effect by G15 in MCF-7R cells.

To explore a causal relationship between Tam effects and the assembly of the PR/AP-1 complex, we went back to our experimental models.

ERα genomic actions appear not to be involved in progestin nor Tam effects, as we found no recruitment of ERα to the AP-1/PR transcriptional complex in BT474 cells.

Because activated GPR30 at the cell membrane promotes HB-EGF release to activate the EGFR signaling pathway, resulting in phosphorylation of Erk1/2 in breast cancer cells, and TAM-R cells (as described above) increase activation of Erk1/2 in response to E2, G1 and Tam, the effect of GPR30 on EGFR signaling was tested in TAM-R cells.

So in the current study, we hypothesized that the combination of MSM and Tam could synergize the anti-BCa effects of tam at an even milder dose, owing to the ability of MSM to inhibit the STAT5b and STAT3 signalling pathways.

To investigate to what extent IGF-1R signaling causes this 4-OH-TAM agonistic effect, cells were coexposed to 4-OH-TAM in doses of 10, 33 or 100 ng/mL IGF-1, which were shown to cause different levels of sustained receptor and downstream signaling activation.

Consistently, IGF-1 promoted a 4-OH-TAM promitogenic effect in MCF7/IGF-1R cells but not in MCF7 cells, with the highest potential occurring at 4-OH-TAM 10-9 to 10-8 M.