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Zoic Studios provided the visual effects seen in the pilot, building virtual sets for the fairy tale sequences and using F/X for action scenes.
TALE sequences were designed to 20 bp regions within the Scl+40kb and PU.1-14kb elementhathat were conserved between human and mouse, and were unique within both genomes by BlastN and Blat (Altschul et al., 1990; Kent, 2002).
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The result is nine scenes encapsulating the broad brush strokes of the tale, combining animated sequences for moments like the birth of the Monkey King with Chinese acrobatics, fight sequences and clowning.
The Sox2-TALE-TF binding sequences were deduced from the Sox2 effector binding domain, and used for construction of its dual reporter.
Crystallographic studies of TALEs bound to their target sequences unraveled that TALE DBD forms a right-handed superhelical assembly wrapped around B-form DNA duplex and explained specific repeat-nucleotide interactions [ 15, 23, 24].
Here is a tale in which battle sequence spawns battle sequence and where the dialogue is rendered all-but unintelligible under the din of clashing steel and the screams of the mutilated.
TALE repeats have similar sequences and differ only in the two highly variable amino acids at positions 12 and 13 (RVDs, repeat variable di-residues), which form the basis for specific-nucleotide recognition.
And the grand narrative poems of his "Tale of a Wayside Inn" sequence have a dramatic thrust and vivid portraiture that can evoke one's first, enthralled experiences with stories, the high adventurous romance of those books that helped shape our desires and still abide in our memories.
Bodiam Castle was used in Monty Python and the Holy Grail in an establishing shot identifying it as "Swamp Castle" in the "Tale of Sir Lancelot" sequence.
"Piglet's Big Movie" cleverly compacts several Milne tales into a sequence of anecdotes illustrating the heroism of the little pig who, being the smallest member of the Pooh tribe, is underappreciated by his friends.
As of last weekend, Curzon is now warning viewers: "Following the Germanwings flight incident on Tuesday 24th March, please be aware that Wild Tales features a sequence that some customers might find disturbing".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com