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Previous studies taking unbiased chemical screening approaches to identify anti-proliferative agents were limited by screening assay output, chemical library composition, lack of chemical analysis on hits, and a narrow focus on specific phases of the cell cycle.
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In retrospect, science was not good at guessing which genes contribute to genetically complex phenotypes; it took unbiased genome-wide surveys to identify such genes.
For now, Michael Griffin, Patterson's supervisor, said he was taking an unbiased stance.
It is about taking an unbiased look at what we do know and what we need to know to create the safest vaccine that actually works to prevent breast cancer in women.
In conclusion, we have identified several novel substrates of HDAC8 by taking an unbiased approach coupling chemical tools with acetylome profiling.
We maintain our position of not accepting advocacy ads, a standard industry practice, and have a great deal of faith in young people's ability to take in unbiased information and decide for themselves.
Writing in the journal Foreign Affairs, he argued that in decades past the Communist Party took relatively unbiased positions on economic matters, allowing it to defy vested interests and choose pro-growth policies.
"If you take an unbiased look at the situation, there was a rapid decline of living standards in the nineteen-nineties, which affected three-quarters of Russian families, and all under the 'democratic banner.' Small wonder, then, that the population does not rally to this banner anymore".
"This allows us to take an unbiased numbers-based approach that other political tools lack.
Recent technological developments in genomics, proteomics, metabolomics, are allowing researchers to take an unbiased 'big-picture' approach to further elucidate the molecular pathogenesis of lung injury [6] (Figure 1).
Finally, writer-director Chip Duncan takes an "unbiased" which is to say sober but not terribly insightful look at The Reagan Presidency in a three hour work best at illuminating his decisive part in ending the Cold War alongside Mikhail Gorbachev.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com