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We take an alignment approach to the construction of our tertiary structure dataset from the quaternary structure data.
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The SIA algorithm takes an alignment as input.
Next, a subroutine GREEDY_ALIGNMENT (A, F') takes an alignment A and a set of fragments F' as arguments and returns a new alignment A' ⊃ A by adding fragments from the set F' in a 'directly' greedy fashion.
Simulfold takes an alignment as an input and simultaneously calculates a structure including pseudoknots, a multiple-sequence alignment and an evolutionary tree by sampling from the joint posterior distributions (Meyer and Miklos, 2007).
Tfold and hxmatch take a sequence alignment as the input.
Several of these methods take a sequence alignment as an input.
To the best of our knowledge, filters for multiple repeats that take a multiple alignment condition into consideration have been addressed only in [ 15, 16].
Some studies have suggested that the main role of the conserved Tyr is to stabilize the cluster through these aromatic and H-bond interactions and not to have any profound effect on the reduction potential; however, because the Tyr in different proteins tends to take a different alignment, this hypothesis cannot be generalized to all HiPIPs.
This method takes an initial alignment and constantly makes changes to it.
It takes a certain alignment of political and geographical factors to give birth to a tradition like this one.
KNetFold is a machine learning method, which takes a sequence alignment as an input and outputs a consensus structure allowing pseudoknots (Bindewald and Shapiro, 2006).
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