This exhibits the nature of the problem and suggests the need to tailor trial sequences to specific applications.
On the other hand, more complex adaptive trials can be designed to identify the most promising treatments for specific subpopulations within a disease and tailor trial enrollment and randomization to maximize the information gained [ 10].
We need a formal assessment of the external validity of RCTs in general, and these will have to be tailored to trials in infectious diseases because of the unique considerations in the external validity of these studies.
Natural history studies will identify the anatomical levels where disease progression is actively evolving in specific patient groups, allowing optimally efficient, anatomically-targeted protocols to be tailored to specific trial applications.
However, in tailoring clinical trials, Comparison 3 is generally statistically insignificant.
Moreover, it may also be of interest to evaluate the impact of exercise trials tailored for members of the general public.
Increasingly common are trials tailored to detect enhanced efficacy in a patient subpopulation, e.g. patients with a known biomarker value or whose tumors harbor a specific genetic mutation.
The collaborative care model has been found to be effective for depression management in various primary care populations; however, no review has synthesized trials tailored to treat women.
The original algorithm is now freely available upon request, but Origent hopes to market programs that can be tailored to specific clinical trial designs or even used to help doctors make more personalized predictions for their patients.
