The advantage of our genome-wide transcriptional analysis over single protein or tailored pathway specific approaches was to further the ability of analyzing the data in an integrative manner and to detect system level convergence of pathways that were previously believed to be distinct.
Figure 5 The presumable post-PKS tailoring pathway of bafilomycin B 1. (A) The presumable biosynthetic pathway of methoxymalonyl-ACP from 1,3-bisphophoglycerate. (B) The presumable biosynthetic pathway of flavensomycinyl group from glycine, succinyl-CoA and fumaryl-CoA.
The schools with outstanding professional development models encourage tailored CPD pathways for the individual teacher and support members of staff throughout the year in dropdown sessions and after-school groups.
Seamless information, communication, coordination, patient involvement and shared decision-making ensure that the patient experiences a coherent and individually tailored care pathway within the existing framework of the health care system.
The article CyKEGGParser: tailoring KEGG pathways to fit into systems biology analysis workflows by Lilit Nersisyan, Rouben Samsonyan and Arsen Arakelyan presents a comprehensive software tool allowing to edit KEGG pathways based on additional information taken, e.g., from tissue expression data and/or protein interaction networks.
In this review we analyze possible reasons for the limited efficacy – including the diverse and sometimes even contradictory effects of active Ras pathways in tumor cells – and propose possible alternative methods of tailoring Ras-pathway inhibitor combinations for cancer therapy.
Our informatic and functional analysis suggest that, by this expansion, Tetrahymena expresses a set of tethers that have been tailored for individual pathways.
Most bacteria have evolved tailored carbon utilization pathways and regulatory schemes for the uptake and catabolism of carbon sources in their environment.
Planners need to assess the compatibility of the telestroke service with existing technical and clinical systems, and agree governance procedures and clinical pathways tailored to local circumstance [ 30- 33].
While the diagnosis and treatment of cancer has historically been based upon histologic findings and extent of disease, cancers are now being reclassified by molecular subtype, with treatment tailored to the pathways mutated.
