Limsopatham et al. [ 38] attempts to improve IR on health records by inferring implicit domain knowledge, mainly done through query expansion that relies on tailored domain-specific resources and information from other high-ranked documents.
However, additional auxiliary domains, also known as tailoring domains, may also be present within each module, which creates structural diversity within the encoded natural product.
Acetylation is not the only post-translational modification that attracts proteins with a specifically tailored recognition domain.
One reason is that medical NLP programs are often tailored to domain or institution-specific document formats and other text characteristics.
While the general module architecture was conserved within a gene cluster type, frequent tailoring domain rearrangements were shown resulting in new features like the G-domain, and OciH of the cyanopeptolin and partial halogenases in OciG and AerB.
Detailed kinetics studies using model substrates of varying length will provide insights into the substrate specificities of these tailoring domains.
This variety stems from their intrinsic programming rules, which permutate the use of tailoring domains and determine the overall number of iterative cycles.
HRPKSs also consist of a set of tailoring domains, including ketoreductase (KR), dehydratase (DH), enoylreductase (ER), and the Cα-methyltransferase (MT).
Most notably, the HRPKSs use the single set of tailoring domains in different permutations during every extension cycle, which results in the high degree of variability at individual α- and β-positions in the products.
The system always appears to the user as if it was especially tailored for his domain.
