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The technique offers a potential way to generate genetically tailored cells without destroying human embryos.
Genetic modification of human bone marrow stem cells (hBMSCs) before administration to a patient is emerging as a viable approach to creating tailored cells that perform effectively in a clinical setting.
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With this methodology, we tailored cell membranes with β-cyclodextrin and subsequently manipulated cell behaviors through introducing photo-switchable guest molecule.
Furthermore, we summarise the exciting recent developments in strategies to target HSC specifically, and novel techniques to deliver pharmaceutical agents directly to HSC, potentially allowing tailored, cell-specific therapy for HCC.
Molecular release from scaffolds is desired for tailoring cell-compatible tissue engineering.
The moderate performance achieved by existing methods (see next section) have led us to develop a new cell-specific model building method termed PRIME (Personalized ReconstructIon of Metabolic models), which utilizes both molecular and phenotypic data for tailoring cell-specific GSMMs.
In a virtuoso display of cutting-edge techniques, a team combined cloning, embryonic stem cells, and gene therapy to treat immune-deficient mice with genetically tailored stem cells.
Microbial cell arrays have attracted consistent attention for their ability to provide unique global data on target analytes at low cost, their capacity for readily detectable and robust cell growth in diverse environments, their high degree of convenience, and their capacity for multiplexing via incorporation of molecularly tailored reporter cells.
We review here developments and current concepts in adoptive T-cell therapy, and discuss whether such concepts may aid to offer tailored T-cell –based therapy for patients with refractory MDR and XDR tuberculosis, who may have limited or no other treatment options.
Clearly, it is the high plasticity of these processes that is instrumental to drive tailored B cell responses that protect the host.
Then a two-stage culture process was exercised with these optimal conditions tailored for cell growth (first stage) and carotenoid accumulation (second stage), achieving 95.8% higher volumetric yield (18.6 mg/L versus 9.5 mg/L in the single-stage culture) and 22.6% higher volumetric productivity (2.33 mg/(L day) versus 1.90 mg/(L day)) of total carotenoid.
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