For these proteins, folding occurs over a relatively rough landscape whose energy maxima and minima can be tailored by alterations in sequence, temperature or solvent conditions.
As for the device color, it can be tailored by alteration of the electrolyte thickness.
Small-molecule tyrosine kinase inhibitors (TKI) tailored for oncogenic 'driver' alterations have shown unprecedented success in molecularly selected NSCLC patients harboring epidermal growth factor receptor (EGFR) mutations (EGFR TKI: gefitinib, erlotinib, and afatinib), or anaplastic lymphoma kinase (ALK) fusion gene (ALK TKI: crizotinib, alectinib, ceritinib) [ 3, 4].
This has mainly resulted from the identification of molecular alterations in relevant intracellular signaling pathways—Hedgehog, PI3K/AKT/mTOR, Notch, ErbB, MAPK and angiogenesis which are potential tailored targets for gallbladder cancer patients.
Get your clothing tailored just for yourself.
There are browsers tailored specifically for media.
Usually, the costumes are tailored for a specific actor, then kept around in case the school can use them again — sometimes with an alteration or two for size.
B lymphocytes use two DNA alteration mechanisms, class switch recombination (CSR) and somatic hypermutation (SHM), to re-engineer their antibody gene expressing loci until a tailored antibody gene for a specific antigen is satisfactorily generated.
This is relentless checking, tailored for television.
American sports have been tailored for television.
And they are tailored for specific audiences.
