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The release pattern from a multi-regions device was consistent with the wetting pattern, demonstrating the possibility to tailor the release according to periods of peak demand.
Anionic or non-ionic surfactants have been introduced in agarose-based hydrogels aiming to tailor the release of drugs with different solubility.
We demonstrate that both an accurate control of the fiber microstructure as well as the fiber composition is important to tailor the release kinetics of a model compound.
The current results demonstrated that the designed biphasic composite approach could potentially be a good way to tailor the release of Zn through combinations of different Zn chemical states, with the durability of the coatings not impaired.
Adjustments in SF crystallinity, concentration and structure, the design of the delivery systems as well as the molecular weight and structure of the embedded agents represent important variables when it comes to precisely tailor the release kinetics of SF matrices.
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This trend suggests that molecular engineering of the hydrogelators to control the MGC values should be effective and useful for tailoring the release profiles of the chemoattractants.
The scaffolds were effectively associated with TGF-β1 and allowed to tailor precisely the release of the growth factor from 12 days to more than 50 days by varying the copolymer composition of the coating.
In summary, the control of alginate core size in the alginate-PLGA core-shell microparticles proved to be an effective way to tailor the drug release profile.
These systems are thought to be versatile enough to allow the inclusion of substances (such as the surfactants tested: Pluronic, Tween, Na Lauryl sulphate) that may contribute to tailor the drug release patterns.
The great thing about 'ZinePaks is that every one is totally different, and the content inside is tailored to the release and to the fans.
The method described in the paper also makes it easier for us to tailor the drug releasing profile together with the other methods to gain the best therapy effect.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com