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Title compounds were designed as dual drugs for tackling simultaneously the Gaucher disease (by selective inhibition of β-glucosidase, Ki = 1.6 5.5 μM, with improved potency and selectivity compared to deoxynojirimycin) and its neurological complications (by inhibiting AChE, Ki up to 5.8 μM).
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A wide range of contributing factors needs to be tackled simultaneously, with no guarantee they will have a substantial impact any time soon.
For the first time this is creating an opportunity for proponents of parallel processing on a single chip ie, a processor that breaks tasks down into lots of little jobs that are then tackled simultaneously.
And it calls on the Israelis and Palestinians to deal first with borders and security, contrary to Israel's position that all final status issues are interlocked and must be tackled simultaneously.
The use of hydrogen donor molecules from renewable origin can be a promising alternative to tackle simultaneously with both objectives.
In this paper we tackle simultaneously the problems of cluster validation (i.e. model selection), feature selection and outliers rejection when clustering positive data.
Recent scientific advances have shown that multiple deficiencies can be tackled simultaneously using engineered plant varieties containing high levels of different minerals and organic nutrients.
In this article, the issue of effective, dynamic I-frame insertion, and reference frame (termed as the McFIS) generation in video coding has been tackled simultaneously with a Gaussian mixture-based model for dynamic background.
Thus, against the background of several societal challenges waiting to be solved, and financial and human resources limitations meaning not all topics can be tackled simultaneously, the authors suggest a generic approach that closes this loophole in current knowledge.
This approach involves only a single decomposition of the dynamic stiffness matrix for the entire simulated structure and the facility that several stochastic fields can be tackled simultaneously are basic advantages of the Neumann Expansion.
In a near future, these developments will allow to tackle simultaneously imaging and dosimetry issues and soon, case system Monte Carlo simulations may become part of the nuclear medicine diagnostic process.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com