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For the TCSPC module, the time-to-amplitude converter (TAC) range is set to 70 ns and the biased amplifier gain to 1. Since the TAC output is resolved into 4096 time-bins by a 12-bit analog-to-digital converter, the above settings lead to a bin-width, i.e., sampling time interval, of Δ t ≈ 17.1 ps.
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In particular, this dynamic acquisition provided 11 frames of 5 min each, leading to 11 data points of the experimental 18F-FDG IF and of the experimental cancer tissue TAC, ranging 7.5 57.5 min post-injection.
Among 13 healthy subjects, aged 18-22y, TAC ranged between 1.26 and 1.89 mmol/l [ 71].
The number of reads aligned to a TAC ranged from 1 to 22,846, with a mean of 62.2 for Dry, 46.5 for R2 and 42.9 for R24.
Root-mean-squared error calculated for the fitted TACs ranged from 0.31 to 1.14 %ID/g for 124I-J591 and from 1.06 to 7.18 %ID/g for 89Zr-J591.
The GDCs models' decay corrected mean residence times (MRTWO) of 99mTc-MIBI in the thyroid TACs ranged from 211.6 to 699.0 min.
Results show that TaC coating thickness ranges from 14.4 ± 1.59 to 354.3 ± 2.89 μm depending upon the treatment time and temperature.
It should be noted that the tacrolimus C0 concentration in the EVR+Reduced TAC group was in the range of 5 6 ng/mL, slightly above the upper extent of the target range (3 5 ng/mL) throughout the study, which may have influenced the results, and suggests that somewhat lower tacrolimus exposure could be explored to further reduce CNI-related nephrotoxicity.
Patients on Tac reached the C0 target range on average by day 11.
Urinary protein to creatinine ratio peaked at month 6 in the EVR+Reduced TAC group (median 105 mg/g, range 33 4143 mg/g), and at month 2 (median 108 mg/g, 39 10,370 mg/g) in the TAC Control arm.
The mean gestational age at the time of TAC was 13.5 weeks (SD 0.8; range, 12 15).
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