Exact(15)
These NIR methods intend to be used for the monitoring of the active content of tablets during the tableting process.
Furthermore, the NIR method based on the transmission mode was successfully used to monitor at-line the tablet active content during the tableting process, providing better insight of the API content during the process.
Tableting process parameters were adjusted to obtain uniform tablet weight and thickness.
Differences between laboratory and commercial tablet presses are frequently observed during scale-up of tableting process.
Scale‐up issues in the tableting process, such as capping, sticking, or differences in tablet thickness, are often observed at the commercial production scale.
Therefore, understanding the physiochemical properties of ingredients and the mechanical behavior of powders during tableting process is very important for the quality of tablets with mechanical strength as one the profound parameters.
Similar(45)
According to the quality by design concepts, critical quality attributes (CQAs) of granules and tablets, as well as critical parameters of granulation and tableting processes, were identified and evaluated.
The higher the friction/cohesion force, the poorer the flowability, but free flow is essential during capsule filling or tableting processes.
These approaches are considered to have a potentially large impact on quality monitoring and control of continuously operating manufacturing lines, such as roller compaction and tableting processes.
This study illustrates the application of experimental design and multivariate data analysis in defining design space for granulation and tableting processes.
In the present study the application of near-infrared chemical imaging (NIR-CI) supported by chemometric modeling as non-destructive tool for monitoring and assessing the roller compaction and tableting processes was investigated.
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