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Tableting process parameters were adjusted to obtain uniform tablet weight and thickness.
This means that every single tablet (weight: 0.45 g) contains 0.0016 mg of thujone.
However, the variability in tablet weight and content uniformity deteriorated under this condition.
This information can be used to reduce the tablet weight variability and ensure that this critical attribute is met.
The impact of tablet weight and dimensions was evaluated to gain understanding of the effect of scale-up/down of tablet size.
In order to select the optimal process, setting the standard deviation of tablet tensile strength and tablet weight for each tablet batch was considered.
Similar(30)
The strategy consists of an initial physical evaluation by simple measurements of tablet weights and dimensions (Tier I), followed by rapid scanning of the tablets using the CD-3 and CoDI devices (Tier II).
The content of model drug acetaminophen incorporated in the tablets through premixing reached up to 68% of the tablets' weight.
It is shown that different die wall lubrication conditions induce opposite density distribution trends in identical tablets (weight, height, and material).
The non-homogeneous distribution of directly compressed metoprolol succinate beads on the surface of the tablets as well as the split intersection explained the large variation in the split tablets' weight and content uniformity results.
Table 1 Basic data of the antimalarial tablets Tablet samples Weight (mg) Height (mm) Diameter (mm) GN1 241.4 3.08 9.05 GN290.9.4 3.78 9.09 FK1 255.3 3.25 9.14 FK2 255.3 3.25 9.12 The weight was measured using the analytical balance Sartorius 2432 with accuracy ±0.1 mg.
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