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TPI showed high potential in the assessment of intra-tablet uniformity and layer thickness distributions over the whole tablet surface.
The pan rotation speed and pan loading are shown to have a small effect on intra-tablet coating uniformity but a more significant impact on inter-tablet uniformity.
Different measures of intra-tablet uniformity were investigated: the average thickness on the individual tablet faces, spatial variation in layer thickness over the tablet surface, and the coefficient of variation (CVintra).
To measure tablet content uniformity, orbifloxacin tablets with drug content ranging from 60 to 90 mg were made and analyzed using ultraviolet (UV) and NIR spectroscopy.
The results show that both evaluated variables had an impact on the produced granules and tablets as well as tablet content uniformity.
The sifting segregation tester and testing protocol (ASTM D 6940-04) were modified to provide better correlation between the test results and tablet content uniformity.
The DEM results show intra-tablet coating uniformity is strongly influenced by tablet shape, and the extent of this can be predicted by a measure of the tablet shape.
The second algorithm predicts the asymptotic limit of intra-tablet coating uniformity.
It was successfully used to identify critical process parameters regarding intra-tablet coating uniformity.
The objective of this study was to enhance the inter-tablet coating uniformity in an active coating process at lab and pilot scale by statistical design of experiments.
The purpose of this study was to evaluate the intra-tablet coating uniformity and the identification of critical process parameters in an active pan coating process using terahertz pulsed imaging (TPI).
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