The CDMSS used an existing shaker and shaking table platform, and a gas liquid two-phase circulation system, including the monitoring and sampling units.
However, incorporating multiple sensors, irradiators, and detectors in the flask and shaking table platform is unrealistic owing to the small size of the flask.
The co-planar PET/MRI concept (Fig. 2b), first presented in 2010, is based on a tandem design of a whole-body time-of-flight (TOF) PET system and a 3-T Philips Achieva MR system (Philips Healthcare, Cleveland, USA) with a rotating table platform in between.
Currently, to monitor the environmental variables, several sample flasks are prepared and cultured simultaneously, and a single flask is retrieved from the shaking table platform periodically and sampled aseptically to measure the time course of the shake-flask culture of microbes.
An occluder 20 cm above the table platform prevented vision of the hand.
Participants sat on a height-adjustable chair and faced a 15-inch LCD monitor (EIZO FlexScan L365), which was placed in about 100 cm distance from their eyes on a table platform.
In order to perform such an examination, an additional table platform should be mounted on top of the original patient table.
A recent advance in MRI has been the use of whole body multicoil systems and a moving table platform that allows scanning of adjacent anatomical regions without repositioning of the patient or the imaging coils.
All PET/MR scans were performed on a Philips Ingenuity time-of-flight (TF) PET/MR scanner (Philips Healthcare, Cleveland, OH), which is a sequential PET/MR system consisting of a GEMINI TF PET scanner and an Achieva 3-T TX MRI scanner with a common rotating table platform in between [ 6, 16].
In our own preliminary experience using 3D gradient-echo sequence with a rolling table platform, parallel imaging technique and multi-channel phased array surface coil devices, WB dynamic gadolinium-enhanced imaging with 152 images (in-plane resolution 2.6 × 2 mm) encompassing almost the entire bone marrow space is feasible within 60 s (Fig. 4).
