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For further details, including relative fitness values and a table of genotypes, please refer to [ 5].
All genotypic data were from Tenaillon et al. [ 5], which includes a supplementary table of genotypes.
Like most other imputation methods, LinkImpute is applied to a table of genotypes that have been called by a genotype calling algorithm.
For a SNP and CNV, phased haplotypes were estimated using an maximum likelihood, in which the 3 × 5 table of genotypes ([0,1,2,3,4] CN × [aa aA AA] SNP genotypes) was iteratively mapped onto a 3 × 2 table of haplotypes ([0,1,2] CN × [a, A] SNP alleles).
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In the 2 × 3 contingency table of genotype in the 'observed' data produced by the genotyping platforms (Obs).
If we regard Table 1, hypothetically, as a contingency table of genotype counts, then taking row sums (or, equivalently, column sums) corresponds precisely to evaluating the mapping ρ.
The score, UF, for the 3 × 2 table of genotype frequencies in females is weighted by 1/2, while the score, UM, for the 2 × 2 table of allele frequencies is unweighted.
This analysis can be contrasted with testing for association in the 3 × 2 contingency table of genotype (A/ A, A/ a, or a/ a) against phenotype, in which the counts are of subjects.
The partitioned genetic effects may each be represented as a two-way table of genotype by environment effects, and we assume that the variance matrix for the additive genotype effects has the separable form where and are p × p and m × m symmetric positive definite matrices, respectively.
By 2 × 3 contingency table analysis of genotypes, rs1564282 was significantly associated with PD but rs2061846 was not.
The appropriate corrections depend on sample odds ratios of the standard 2×3 tables of genotype by case and control from null loci.
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