Since both cystatin C and α1-ACT are present in urine at concentrations far below those observed in plasma (See Table 2), alterations may simply reflect general proteinuria resulting from compromised renal function.
In conclusion, even for the most simple situations described in Table 1, alteration of the predicted TFs results in a cascade of effects, thus confirming that our method is not predicting TFs at random but precisely those which are central for multiple processes.
After a profile has been appropriately annotated, a table of detected alterations can be displayed by clicking the 'Show alterations on the UCSC genome browser' link shown on the bottom of Figure 1.
Importantly, there were no differences between Conditions in objective back stiffness (AvgStiff and TermStiff) as a function of Indent number or Group for either of the above comparisons (Supplementary Figure S3 and Table S2): perceptual alterations were not accompanied by changes in biomechanical stiffness.
The preoperative immunophenotype of RCC patients with 'early' (<pT3) and advanced (≥pT3) stage tumors were compared to investigate tumor stage-dependent alterations (Table 1).
The overall porosity deterioration with depth is about five porosity units per 1000 m (Fig. 5), and this trend is presumably a result of mechanical compaction combined with the effect of diagenetic alterations (Table 1).
On the other hand, CdS and VC populations occupy open, circulating coastal waters and they display high levels of gene flow and predominant rates of lethal alterations (Table 4).
All five of the novel amino acid substitutions represent non-conservative changes that are consistent with previously described alterations (Table 1): A97T (nonpolar to polar), D112N (negative to neutral), V122E (nonpolar to polar-negative), V122G (aliphatic to non-aliphatic), and L188H (nonpolar to polar-positive).
NGS identified a broad range of molecular alterations (Table 2; Additional file 3).
Electron microscopy studies are summarised in Figure 3 and Table 3. Ultrastructural alterations in microvilli varied from elongation to atrophy.
Genes co-located with the indel mutations in some cases did show expression ratio alterations (Table 6B).
