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Today, the field of contemporary toxicity testing needs well-validated suites of cellular systems that examine relevant biomarkers for critical physiological effects (Eisenbrand et al. 2002).
We and others evaluating new toxicity testing strategies believe that the answer here is the development of high throughput systems that examine specific precursor responses, i.e., specific response biomarkers, in appropriate in vitro test systems.
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This result is consistent with other overexpression cell systems that examined Ron/EGFR interaction (Peace et al, 2003).
For their part, patient groups and some doctors applauded the panel's finding, saying that it was urgent to create a system that examined a device's benefits and harms before large numbers of patients were exposed to it.
The new configuration, APEX-CE, will be used to perform a series of separate effects and integral systems overcooling tests that examine the conditions that lead to primary loop stagnation and cold leg thermal stratification.
The development of novel embryo-derived model systems, combined with methods that examine chromatin status and chromosome conformation, led to deeper understanding of the process of Hox activation in the early embryo.
This combined with spatial aspects forms social ecological models, which are a component of the fast developing systems science that examines multiple effects and interrelatedness of social elements in an environment (11).
The fact that the two endpoints tracked demonstrates the functional coordination of the two organs during ileus and illustrates the necessity for endpoints that examine system wide function in order to develop a complete understanding of the mechanisms of ileus.
In the context of systems-biology approaches, methods that examine protein-protein interactions are particularly informative because they evaluate the effect of mutations on the complex network of cellular interconnections.
MM is an anthropologist and involved in three longitudinal, transdisciplinary research projects that examine pastoral systems within the analytical framework of coupled human and natural systems.
MM is an anthropologist and involved in several longitudinal, transdisciplinary research projects that examine pastoral systems within the analytical framework of coupled human and natural systems.
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CEO of Professional Science Editing for Scientists @ prosciediting.com