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Also clu, a gene expressed at low levels in the central nervous systems of embryonic mice before increasing during postnatal life [ 35], was similarly up regulated during the axolotl and tiger salamander larval periods.
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Here I discuss the complex structure function relationship of the mammalian genome using the model system of embryonic stem cells, and the progression from pluripotency to terminal differentiation and back again.
Using the well-established in vitro system of embryonic NSC [16] we identify p73 as a positive regulator of these cells since neurospheres derived from p73−/− mice proliferate less than wild-type neurospheres and show dysregulation of several genes involved in NSC self-renewal.
Primary cells were obtained from central nervous system tissue of embryonic mice and cultured primarily as previously described [ 29- 31].
Here we describe a three-dimensional, long-term in vitro-culture system of the embryonic chick retina which supports photoreceptor development.
We have developed an ex vivo culture system of whole embryonic chick femora, adapted in this study as a critical size defect model to investigate the effects of novel bone extracellular matrix (bECM) hydrogel scaffolds containing spatio-temporal growth factor-releasing microparticles and skeletal stem cells on bone regeneration, to develop a viable alternative treatment for skeletal degeneration.
* One reason for nature choosing to use the lateral inhibition system of the embryonic neurogenesis rather than the N on/N off Numb-biased choice might simply be the goal to achieve: in one case, a few neuroepithelial cells in the embryo decide to become neuroblasts while the majority remains epithelial (a case similar to the DCNs where the majority of neurons retracts to the lamina).
Reporter-gene expression patterns demonstrated that they are active either inside and/or outside of the nervous system during stages of embryonic and postembryonic development.
In mammals, a wide variety of cells use the Notch signalling system for embryonic development and maintenance of homoeostasis in adults.
As the current methods cannot meet the requirements for large-scale embryo-electronic systems, this article advances a new shift-register-based configuration memory of embryonic system to solve the problem by using the inter-cell communication to reduce the gene storage capacity of a single cell.
Finally, very helpful scoring systems for the evaluation of embryonic development and wound healing could be identified (Table 8).
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