In the present study, we investigate the effects of exposure to environmental low-level polluted water for distinct exposure time and developmental windows, with a focus on liver toxicity in two model systems, mouse and zebrafish.
Here, we attempt to examine the prevalence of trans-effects and their potential impact on gene expression patterns in vertebrate evolution by comparing the function of identical human tissue-specific enhancer sequences in two highly divergent vertebrate model systems, mouse and zebrafish.
The secondary system used was the EnVision™ Plus HRP (horse radish peroxidase) system (mouse and rabbit).
Researchers must take advantage of these to test specific, well-controlled hypotheses in human subjects, model systems (mouse, zebrafish and others [ 97]), and in vitro (for example, cell culture and functional screens).
Experimentally, different constructs and protein expression systems, mouse models and Notch ligands (soluble or immobilized) were used.
These disagreements about the mechanism of caloric restriction are confined to yeast, but may portend future disputes in the far more complex systems of mice and men.
In this chapter, we review our findings and other key experiments that have led to the establishment of the current cellular stem and progenitor hierarchy in the blood-forming systems of mice and humans for both normal and leukemic hematopoiesis.
We used two experimental systems (MAFIA mice and CCR2−/− mice treated with a migration-blocking antibody) that allow significant reduction in the numbers of these cell subsets in deep tissues.
Transgenic labelling techniques have also been used to show that various cell types in the olfactory systems of mice and chicks are derived from neural crest cells.
Although the immune systems in mice and humans differ, it is still informative to check the immune responses and evaluate the potential of these experimental vaccine candidates in mice.
