The present study was designed to determine the presence of CT-1 and the gp130 cytokine system in vascular endothelial cells and to investigate whether CT-1 stimulates synthesis and secretion of ET-1 in the vascular endothelial cells.
Recently, RAS is a critical system in vascular biology and recently in neuroscience.
We study the Nox1 system in vascular smooth smucle cells and propose four potential disassembly mechanisms.
The present study aimed to investigate the effects of the renin-angiotensin system in vascular protection mediated by PPARγ agonists.
To investigate the actions of the renin-angiotensin system in vascular protection mediated by activation of PPARγ in vivo and in vitro.
PPARG activators may play a role in hypertension and atherosclerosis through modification of inflammation and the innate immunity system in vascular cells (13, 14).
Accumulating evidence from animal and human studies points to the involvement of the Ang/Tie system in vascular barrier dysfunction during critical illness.
Angiotensin II, the more extensively studied peptide of the system, stimulates AT1R (mainly associated with vasoconstriction) and AT2R (associated with vasodilation) but recently the role of other components of the system in vascular tone has also been considered.
Furthermore, significant inductions of PAI-1 (mRNA and protein) and uPAR (uPA receptor) (R. L. Benton, unpublished data) in ECs after ischaemic SCI suggest a role for the PAS (PA system) in vascular dysfunction and secondary injury progression following SCI, as has been established in stroke.
