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WOX1 expression is upregulated in the early stages of developing central and peripheral nervous systems in mouse embryos [16].
These relationships are derived from a myriad of experimental systems in mouse, rat and human.
When coupled with the scalability, ease of generating transgenics and the imaging capability of the zebrafish, these loss-of-function tools will likely provide an important complement to similar knockout and knock-down systems in mouse.
Over the past 20 years since the identification of the causative gene in DM1, significant progress has been made in understanding the pathogenic mechanisms involved in the adult onset form of this disease, including the generation of numerous animal model systems in mouse, C. elegans and Drosophila (Mankodi et al., 2000; de Haro et al., 2006; Mahadevan et al., 2006; Orengo et al., 2008).
Although some of these discrepancies may be due to the use of different transgenesis systems in mouse and zebrafish, in some instances we found an association between differences in enhancer activity and changes in the endogenous gene expression patterns between mouse and zebrafish, suggesting a potential role for trans-changes in the evolution of gene expression.
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We know, for instance, that if you start manipulating DNA repair systems, in mice say, sometimes you get what looks like accelerated ageing.
A task was therefore developed, challenging the visual, vestibular and somesthesic sensory systems in mice.
This study was designed to investigate dopaminergic and purinergic systems in mice with ablations of individual dopamine or adenosine receptors.
There are three primary conditional bitransgenic inducible systems in mice.
In contrast to colitis model systems in mice [ 33- 35], we did not observe alterations in the cytoplasmatic tight junction protein ZO-1.
However, how stromal AR influences oncogenic epithelium cell growth, especially in the real physiological condition with intact immune systems in mice, is still unresolved.
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