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The lack of cellular and animal model systems has hampered progress in the field.
This ubiquity, together with the absence of suitable in vitro culture systems, has hampered progress in the investigation of this group of viruses [ 14].
The lack of efficient cell culture systems has hampered detailed studies on HEV biology, critical for helping to develop diagnostic assays and vaccine research.
Nevertheless, the absence of more complex human model systems has hampered our ability to gain insight into the molecular function of PPARα in human liver, in particular with respect to target gene regulation.
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Federal and state regulations that focus on legacy 911 systems have hampered NG911 deployment.
And the sclerotic nature of our political system has hampered our ability to draw upon that second kind of response to danger.
Gene therapy has shown promising results in the treatment of both inherited and acquired genetic diseases; however, lack of a safe and efficient nucleic acid delivery system has hampered its widespread use [ 1– 3].
However, lack of biologically relevant animal models of chronic HBV infection and efficient HBV infectious cell culture system has hampered our investigation toward understanding of the HBV immunopathogenesis and molecular mechanism of cccDNA metabolism/functional regulation as well as search for immunotherapeutic regimes and cccDNA-targeting antivirals 123, 124.
Perhaps one of the most daunting developments in the relief effort has been the collapse of communication systems, which has hampered emergency medical workers and separated families.
This study found that failure to coordinate human resources, funding and information systems across key agencies has hampered the delivery of integrated PHSHT services.
In addition to the variable genetic architecture presented by IHAPs in several microbial genomes, low level of sequence identity between components of the system in different bacteria has hampered the identification of new T6SS loci.
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CEO of Professional Science Editing for Scientists @ prosciediting.com