Sentence examples for systems for toxicity from inspiring English sources

Expert systems for toxicity prediction are based on a number of methodologies, each with its own strengths and weaknesses.

The microfluidic approach offers several advantages over macro-scale systems for toxicity screening, including low cost and flexibility in design.

In conclusion, understanding the role of the immune system and NPCs in drug-induced hepatotoxicity is fundamental for our interpretation of molecular mechanisms of toxicity and for establishing new and improved in vitro systems for toxicity testing.

As a proof of concept of the potential use of these cell systems for toxicity assessment, effects of acetaminophen were studied in HepG2 cells infected with an adenovirus construct harboring CYP2E1 (Bai and Cederbaum 2004).

Grading systems for toxicities in different studies were checked for consistency and were converted into NCI-CTCAE 3.0 grades.

Thus, if all above-discussed severe limitations are strictly taken into consideration, the following crude generalizations for the xenobiotic metabolism-related relative appropriateness of test systems for toxicities and/or pharmacological activities of compounds coming in contact with the human skin may be attempted.

The main aims of the present study were i) to develop the best culture and maintenance conditions for these cell types (an improved culture medium, appropriate scaffolding systems and the optimal flow rate) in order to create a multicellullar co-culture flow system and ii) to check the feasibility of this multicellular system for toxicity screening on each cell type separately.

Based on this, the usefulness of risk considerations in the current EU classification system for toxicity to reproduction as well as potency considerations will be discussed and suggestions will be made to improve the basic requirements for chemical testing which have remained relatively unchanged over the past 20 years.

C6 glioma cell line is well-established in vitro model system for toxicity studies due to its astroglial origin.

A suitable system for toxicity grading needs to be chosen, taking into consideration the nature of adverse reactions that may occur.

Once a system for toxicity grading has been chosen, a toxicity rules algorithm is developed for the proposed study, taking into account toxicity grading, severity/seriousness, reversibility, "expectedness" and frequency.