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In the design of computer-aided diagnosis systems for lung cancer diagnosis, an appropriate and accurate segmentation of the pulmonary nodules in computerized tomography (CT) is one of the most relevant and difficult tasks.
Concurrently, preliminary data revealed that coated, drug-loaded AuNBs could efficiently deliver a chemotherapeutic agent to A549 cells, corroborating the hypothesis that AuNBs could be used in the future for the development of personalized nano-enabled systems for lung cancer treatment.
In search of such nanoscale theranostic systems for lung cancer, materials such as polymers, metal composites, and other bio-nano approaches have been sought after.
The most commonly used polymer systems for lung cancer therapeutics includes poly(ϵ-caprolactone) (PCL), polylactic acid (PLA), poly(lactide-co-glycolide) (PLGA), alginic acid, gelatin, and chitosan.
CADe systems for lung, breast, colon, liver and prostate cancer as well as for coronary stenosis and pulmonary embolism have been studied recently and found clinical acceptance [ 21– 27].
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Lung adenocarcinoma cells (A549) were used to verify the efficacy of the designed system for lung cancer treatment [58].
In an attempt to develop such a theranostic system for lung cancer, these NPs, along with the anticancer drug doxo, were encapsulated within MFM system.
CONCLUSIONS: Revisions to the TNM classification system for lung cancer should include grouping cases with malignant pleural effusions and cases with nodules in the contralateral lung in the M1a category, and cases with distant metastases should be designated M1b.
The nanoscale lung cancer therapeutic agents encompass nanoscale formulations of metal nanoparticles, chemotherapeutic drugs, and herbal extract, whereas nanoscale delivery system for lung cancer includes metal nanoparticles, polymeric nanoparticles, liposomes, and protein cages.
In one such attempt to fabricate liposome-based drug delivery system for lung cancer therapy, a group led by Zhao L in 2011 fabricated Tween-80/HSPC/cholesterol liposomes of 501.60 ± 15.43 nm diameter loaded with PTX.
(www.adjuvantonline.com) is a prognostic system for lung cancer, breast cancer, and colon cancer based on traditional pathological features, including age, tumor stage, and grade.
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