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Environmental agents that affect other systems during development may lead to downstream effects on the developing brain.
Our results indicate that relative activity patterns across sensory systems during development contribute to modality assignment of cortical fields as well as the size of cortical fields.
Possible mechanisms involve metabolic biology affecting integrity and stability of physiological systems during development and ageing.
Understanding of the importance of glycan function in the nervous and immune systems during development has only recently emerged.
Compelling evidence shows a coordinated interaction between the nervous and the vascular systems during development and in adult brain [ 90].
Interactions between neural systems during development will also make it difficult to isolate primary and secondary causes.
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Neural connections develop throughout the auditory system during development to form the necessary circuits.
Neurogenesis is not only essential for the formation of the nervous system during development, but also critical for the maintenance and neural repair in the adult brain (Feliciano et al., 2015; Zhao et al., 2008).
Our findings suggest an important function of miRNAs during axon extension towards the midline, directly or indirectly, to ensure the appropriate wiring of the nervous system during development.
Thus the proposed principles of selection could be implemented in the adult system, during development, or exclusively through natural selection over generations.
Meltrin β, an ADAM protein that contains an active metalloprotease domain, is strongly expressed in the heart and peripheral nervous system during development [16], [17].
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