Creating lists of the differentially expressed genes is only the starting point of gaining biological insights into experimental systems, developmental stages, or specific disease scenarios.
We report the construction and analysis of a low redundancy 'unigene' set of 27,513 clones that represent a variety of soybean cDNA libraries made from a wide array of source tissue and organ systems, developmental stages, and stress or pathogen-challenged plants.
In systems developmental biology where characterization of complexity of various time course data likely leads to address inference of temporal dynamic patterns from transcriptome, we are not often really interested in exactly how only a single gene is temporally differentially expressed at a particular time point or period.
Analysis of the biological processes in the beating EBs confirms these observations, with overexpression of embryonic and organ system developmental categories including nervous system development, kidney development, skeletal muscle development, and heart development (Table S2 (A8)).
FruM interacts with genes in key nervous system developmental pathways, most notably those involved in neuronal morphogenesis.
RBS is an autosomal recessive, multi-system developmental syndrome caused by loss of function mutation in a gene that encodes a cohesin acetyltransferase, ESCO2 [ 11].
In some tissues and organs, such as the brain, lungs and immune system, developmental vulnerability continues through the neonatal period and perhaps into puberty, thereby extending the period of increased vulnerability to adverse effects from environmental chemicals.
In the analysis of the physiological and system developmental function of this gene set, haematopoiesis featured prominently (Supplementary Figure 3B), together with a high representation of genes involved in the regulation of tissue morphology.
Proteins that were uniquely expressed in the fertile control group only were involved in metabolism, signal transduction and disease, whereas 14% of the DEPs were involved in each category such as immune system, developmental biology, biological oxidations and apoptosis.
With the effects of the WTO's initiatives on international economic governance feeding through the global system, developmental states are obliged to be proactive in their approach to globalisation regardless of their earlier leanings towards protectionism.
Given the strong effect of thyroid hormones on growth and development, especially on the differentiation and maturation of the central nervous system, developmental end points also should be included.
