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The Adverse Outcome Pathways (AOPs) are designed to provide mechanistic understanding of complex biological systems and pathways of toxicity that result in adverse outcomes (AOs) relevant to regulatory endpoints.
We expect that single-molecule fluorescence approaches will continue to be applied to outstanding nucleocytoplasmic transport questions, and that the approaches developed for NPC studies are extendable to additional complex systems and pathways within cells.
Energy systems with high degrees of renewable energy integration require on the one hand energy scenario making and energy system analyses for the optimal design of systems and pathways and on the other hand well-established criteria for decision-making and for characterisation of energy system suitability.
However they also allow more extensive hypotheses, about the roles of different systems and pathways, and of Bdellovibrio-specific genes in predation, or HI growth, to be developed and tested experimentally by the Bdellovibrio community.
Further implementation of this approach would make it possible to study other systems and pathways in individual cells and eventually lead to construction of pathway reporter libraries to study different biological systems at the proteomics level.
When biomolecular binding interactions are "confused" in this way, the result is crosstalk between distinct systems and pathways.
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In addition, BioCyc PGDBs contain information about predicted operons, transport systems and pathway-hole fillers [ 14].
However, two knowledge-bases were also used: Ingenuity Systems and Pathway Studio [ 29].
Functional systems and pathway analyses methods capable of analyzing complex, multi-gene biological phenotypes are rapidly developing and are likely to help in understanding the mechanisms of drug effects.
In fact, metabolism is a complex system and pathways interact with each other.
Gene sets that were validated by the independent validation dataset were matrix metalloproteinases (MMPs) and pathways involved in MMP regulation, the uPA system and pathways involved in uPA regulation, and HIF1α regulated invasion and angiogenesis.
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