Sentence examples for systemically silenced from inspiring English sources
In systemically silenced tissue studied here, DCL1 mRNA levels were found to be strongly affected upon HL growth.
While a construct designed to promote the transient expression of a CrChlI double stranded, potentially hairpin-forming RNA was found to be the most efficient in systemically silencing the endogenous gene, a plasmid containing the CrChlI cDNA insert alone was sufficient to induce silencing.
To analyze the effects of targeting these receptors systemically in vivo, we silenced ADMR on both human cancer cells and on mouse tissue using in vivo delivery of siRNA in DOPC nanoliposomes.
To assess this possibility, STAMP2 was silenced using systemically administered nanoliposomal siRNA in nude mice carrying xenografted tumors of LNCaP or VCaP cells.
Notably, unlike typical siRNA studies, in the current study ADMR was silenced on both the cancer cells and systemically by using siRNAs of both human and mouse ADMR.
The virus spreads systemically throughout the plant with silencing greatest in the second and third leaves above the inoculation site and complete silencing rarely achieved [ 30].
These observations indicated that the BSMV PDS construct could systemically induce gene silencing in all three cultivars and efficiently induce PDS gene silencing in these cultivars.
To validate ADMR as a potential therapeutic target, in vivo studies were conducted using neutral nanoliposomes to systemically deliver human siRNA to ADMR to silence human cancer cells and mouse siRNA to ADMR to silence mouse tumor stromal cells.
In plants, post-transcriptional gene silencing (PTGS) spreads systemically, being transmitted from the silenced stock to the scion expressing the corresponding transgene.
virus-induced gene silencing.
