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Since such peptide nanoparticle constructs are administered systemically in repeated dosages in a clinical setting, it is therefore essential to identify the potential of these constructs to induce an immune response in the mice.
The above work was repeated for FDBs extracted from systemically treated BlaJ mice (total doses of 2 × 10 and 6 × 10vg).
Our repeated observation is that patients with metastatic melanoma who are treated systemically with BRAF inhibitors show remission of extracerebral metastases, but development or progression of brain metastases.
The potential risk of repeated inhibition of PGE2 synthesis at a young age has been demonstrated in experiments with animals systemically exposed to a non-steroidal anti-inflammatory drug (NSAID).
However, the influence of such repeated exposures to high temperatures on parasite growth, development and drug susceptibility have not been studied systemically.
It is also possible that repeated bacteremic events occurring before extraction of periodontally affected teeth (23) might allow oral pathogens to colonize systemically.
Fungal mycelia systemically grow within leaf nervures (stripes); the asexual part of the life cycle is completed within only 14 days, resulting in repeated bursts of sporulating lesions releasing urediospores that infect neighbouring plants.
Repeat: Don't repeat!
The system is systemically corrupt".
"The system is constitutional systemically," she said.
Systemically, alcohol alters multiple arms of the immune system.
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