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Interestingly, systemically increased NET formation has been demonstrated in tumour-bearing mice, as compared with healthy mice160,161.
The data presented in Figure 6B clearly demonstrate that α-MSH secretion in B16-OVA cells was not induced in vivo since we did neither detect systemically increased α-MSH levels in tumor-bearing mice nor locally elevated α-MSH concentrations in the tumor tissue.
Activated leukocytes and vascular endothelial cells contribute to systemically increased concentrations of cytokines and chemokines in patients with sepsis [ 8].
Despite systemically increased 2-AG concentrations in DKO mice, CB2R-mediated signaling remains fully functional, arguing against CB2R desensitization.
Interestingly, the expressions of anti-aging genes such as sod2, foxo and Thor, were systemically increased as a consequence of heart-specific Rpd3 downregulation.
We identified the likely major contributors to HFD-induced decreased latency as local and systemically increased growth factor expression, and promotion of inflammatory and angiogenic processes.
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The SFE is increased by systemically increasing the Mn content from 22 to 28 wt.%.
These data suggest that AMF colonization can systemically increase the phenolic biosynthesis, and SA and H2O2 are possibly the signaling molecules involved.
The proposition that short-term financial activists and reactive corporate behavior spur sustainable improvements in corporate performance, and thereby systemically increase rather than undermine long-term economic prosperity and social welfare, has been overwhelmingly disproved by the real world experience of corporate decision-makers as well as a growing body of academic research.
This, in synergy with insulin, may increase ingestion of "comfort food" and systemically increase abdominal fat depots [1], [6], [7].
Subsequently, the increased circulating levels of DILPs systemically increase growth and metabolism (Lee et al., 2008b).
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