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It was found that the arginase activity is systemically enhanced, but especially pronounced in the active tumor regions.
We found that in comparison to controls, CCL21-vault therapy group had reduced the frequencies of Treg and MDSC and systemically enhanced T lymphocytic lysis of parental tumor cells.
This would suggest that systemically enhanced LDL levels alone are not sufficient to induce joint pathology.
Most tellingly in this regard, a 17-year-old report of systemically enhanced resistance against the rice blast pathogen M. oryzae triggered by a localized infection with the non-rice pathogen P. syringae pv.
Systemically, enhanced support and training may reduce burnout and posttraumatic stress.
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It will be highly interesting to address whether innate immune responses induced by DNA damage in humans might systemically enhance tissue maintenance before chronic inflammation is manifested.
To characterize how heart-specific Rpd3 down-regulation systemically enhances stress resistance, expression of representative anti-aging genes was examined using total RNAs purified from whole flies.
There is a great deal of interest in the development of biologic agents that can be administered systemically to enhance bone repair [ 73].
Besides this physiological situation, osteoclast-mediated bone resorption can be enhanced systemically, leading to increased bone resorption and bone loss as found in postmenopausal osteoporosis.
Thus, systemically decreasing IIS enhances the proliferative potential of PTEN mutant cells.
Systemically administered cytokines, such as interleukin-2 (IL-2), activate the immune system to enhance immune-mediated responses against the tumour, thereby diminishing its metastatic potential [ 19].
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