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It will be highly interesting to address whether innate immune responses induced by DNA damage in humans might systemically enhance tissue maintenance before chronic inflammation is manifested.
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It was found that the arginase activity is systemically enhanced, but especially pronounced in the active tumor regions.
We found that in comparison to controls, CCL21-vault therapy group had reduced the frequencies of Treg and MDSC and systemically enhanced T lymphocytic lysis of parental tumor cells.
This would suggest that systemically enhanced LDL levels alone are not sufficient to induce joint pathology.
To characterize how heart-specific Rpd3 down-regulation systemically enhances stress resistance, expression of representative anti-aging genes was examined using total RNAs purified from whole flies.
Most tellingly in this regard, a 17-year-old report of systemically enhanced resistance against the rice blast pathogen M. oryzae triggered by a localized infection with the non-rice pathogen P. syringae pv.
There is a great deal of interest in the development of biologic agents that can be administered systemically to enhance bone repair [ 73].
Systemically administered cytokines, such as interleukin-2 (IL-2), activate the immune system to enhance immune-mediated responses against the tumour, thereby diminishing its metastatic potential [ 19].
Experiments with systemically applied benzodiazepines, which enhance the action of GABA at these receptors, have suggested both anti- and pronociceptive effects.
These data extend earlier results by demonstrating that a systemically applied benzodiazepine can enhance the rewarding effects produced by central opiate administration.
Despite the limitation of a small sample size used in this study, our findings indicate that considering PELP1 and Ki-67 expression systemically in TNBC will enhance the prognostic sensitivity of the two biomarkers, as high expression of both PELP1 and Ki-67 in tumors is an independent prognostic factor predicting poorer outcome of patients with TNBC.
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