Many smut fungi enter embryos or seedling plants, develop systemically, and appear externally only when the plants are near maturity.
Developing systemically available nanodrug carriers that can target and improve antibiotic properties in the setting of localized acidity may therefore be a method to improve the treatment of these and potentially other infections [9, 10].
Because transgenic mice systemically expressing CagA develop gastrointestinal and hematological malignancies, CagA is recognized as a bacterium-derived oncoprotein.
This scenario is important to consider when developing systemically administered therapies designed to modulate NMD activity (Durand et al. 2007).
Thus, the combinations of antigens and immune signals present in LNs, along with the specific organization of these tissues, help determine the types of immune responses that develop systemically.
In obesity, low-grade inflammation frequently develops systemically and in different organs such as adipose tissue, liver or pancreatic islets, and is thought to play a causative role in the pathogenesis of insulin resistance and type 2 diabetes (Donath & Shoelson, 2011; Lazar, 2005; Weisberg et al, 2003; Xu et al, 2003; Yuan et al, 2001).
All mice developed highly reactive, systemically distributed pools of pMOG35-55-reactive pMOG35-55-reactive pMOG35-55-reactiveecall assays (Fig. 8D).
Cases of accidental or intentional poisoning by ingestion indicate that benzene is absorbed systemically because of the toxicity (central nervous system effects, death) that developed in the exposed individuals (Thienes, 1972).
The infection appears to have had a high attack rate, particularly in children in remote communities, and ≈2% of case-patients either developed meningitis or were systemically sick enough to be admitted to hospital.
New methodologies and innovative data collection systems need to be developed to ensure that the violence and hazards faced by these invisible children become visible on policy agendas and are systemically addressed".
