We have also demonstrated that systemically administered mesenchymal stem cells (MSC) can engraft into injured intestines.
It has been demonstrated that systemically administered AuNPs tend to accumulate mainly in the perivascular regions of the tumor [11], limiting passive accumulation of nanoparticles by the EPR effect to well-vascularized regions of the tumor.
A recent report demonstrated that systemically injected FGF21 stimulates sympathetic nerves innervating iBAT (Owen et al., 2014).
In this report, we demonstrated that systemically delivered BMSCs loaded with sFlt-1 gene could preferentially home to tumor loci and induce anti-angiogenesis as well as apoptosis of cancerous cells, resulting in the decrease of lung metastases and prolongation of lifespan in mouse tumor model.
They demonstrated that a systemically applied almorexant at 30 mg/kg caused a greater reduction in the air-jet stress-induced pressor response in SHRs than in Wistar rats (approximately a 65% vs. a 33% reduction).
Systemically administered kainate has been demonstrated to induce neuronal damage and changes of the levels of biochemical substances related to neurotoxicity.
Interestingly, systemically increased NET formation has been demonstrated in tumour-bearing mice, as compared with healthy mice160,161.
Our study demonstrated the presence of systemically administered the SVS-OH metabolite in the mouse serum by LC/MS analysis.
This study demonstrated that siRNA administered systemically to humans may result in specific gene inhibition by an RNAi-mediated mechanism of action.
In the present study, we demonstrated in vivo that systemically administered scL crossed the BBB, targeted and efficiently delivered a fluorescently labeled ODN payload to both CSCs and bulk tumor cells in intracranial tumors.
