Sentence examples for systemically delivered from inspiring English sources

In addition, several factors, including lack of an efficient vector and delivery system, limit the effectiveness of systemically delivered genes.

The lessons learned along the way are fundamentally important to the design of all systemically delivered nanoparticle nonviral gene delivery systems.

Systemically delivered miRNAs require an efficient system of ensuring intracellular transport, specificity, and metabolic stability to succeed as therapeutic options.

However, systemically delivered exosomes accumulate in liver, kidney, and spleen.

The endothelium imposes a structural barrier to the extravasation of systemically delivered oncolytic adenovirus (Ad).

Magnetic targeting, a promising therapeutic strategy for localizing systemically delivered drug to target tissue, is limited by magnetic attenuation.

However, the combination of IT LPS with systemically delivered VSV resulted in rapid morbidity and mortality in the majority of mice.

The effectiveness of systemically delivered pharmacological therapies against SCI can be limited by the blood spinal cord barrier and side effects.

Efficiency of systemically delivered siRNA in gene silencing is compromised due to lack of target-specific delivery and rapid clearance of siRNA by in vivo elimination pathways.

These systemically delivered ELP drug nanoparticles preferentially localize to the tumor site via the EPR effect, resulting in reduced toxicity and enhanced treatment efficacy.

In recent years, PEI-based non-viral vectors have been locally or systemically delivered, mostly to target gene delivery to tumor tissue, the lung or liver.